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Each ovary is made up of:. Each month, the ovaries release an egg ovum in a process called ovulation. The egg travels down the fallopian tube into the uterus. If the egg is fertilised by a sperm, it will implant itself into the lining of the uterus and grow into a baby. If the egg is not fertilised by a sperm, the lining is shed and flows out of the body through the vagina. This flow is known as a woman's period menstruation. Oestrogen and progesterone cause ovulation and menstruation. As a woman gets older, the ovaries gradually produce less of these hormones.

When the levels of oestrogen and progesterone fall low enough, a woman's periods will become irregular and finally stop. This is known as menopause. After menopause, it is no longer possible to conceive a child. The ovaries also become smaller. There are many types of ovarian cancer. The information below lists the three most common types. Some women usually younger women are diagnosed with a borderline ovarian tumour.

This is not considered to be cancer because, although it can spread, it does not usually invade other organs. For this reason, borderline tumours are also known as low malignant potential tumours. Each year, about Australian women are diagnosed with ovarian cancer. The average age at diagnosis is It is the eighth most common cancer in women in Australia. Ovarian cancer is more commonly diagnosed in women over For an overview of what to expect during all stages of your cancer care, visit Cancer Pathways — Ovarian cancer. This is a short guide to what is recommended, from diagnosis to treatment and beyond.

In its early stages, ovarian cancer usually has no symptoms. This means it is typically diagnosed when the cancer is more advanced. If symptoms occur, they may include: pressure, pain or discomfort in the abdomen or pelvis; swollen or bloated abdomen; appetite loss or feeling full quickly; changes in toilet habits e. If these symptoms are new for you, are severe or continue for more than a few weeks, keep a record of how often they occur and make an appointment to discuss them with your general practitioner GP.

These symptoms can also occur in many other conditions and do not necessarily mean you have cancer, but it is best to have a check-up. Ovarian Cancer Australia has produced a symptom diary to help women record any symptoms and talk about their health concerns with their doctor. Visit ovariancancer. Some women have an inherited faulty gene that increases the risk of developing ovarian cancer. However, not all women who inherit a faulty gene develop ovarian cancer, and not all women with an inherited faulty gene have a family history of cancer.

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Less commonly, Lynch syndrome is associated with ovarian cancer. Other genetic conditions continue to be discovered and are often included in genetic tests for cancer risk. Genetic testing aims to detect faulty genes that may increase the risk of developing cancer.

Many women diagnosed with ovarian cancer are eligible for a Medicare rebate for a genetic test. Your specialist or a familial cancer centre will assess your eligibility and, with your permission, order a blood test to check whether you have the BRCA1, BRCA2 or another similar mutation. Knowing whether you have a particular faulty gene may help determine suitable treatment options see targeted therapy. If the faulty gene causing the cancer is found, Medicarefunded testing can be offered to other family members who have no signs of cancer.

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For more information about genetic testing, talk to your specialist or local familial cancer centre, or call 13 11 Some factors reduce the risk of developing ovarian cancer. These include having children, breastfeeding, using the combined oral contraceptive pill for several years, and having your fallopian tubes tied tubal ligation or removed. Call or email our experienced cancer nurses for information and support. Contact a cancer nurse. Cancer Council Victoria would like to acknowledge the traditional custodians of the land on which we live and work.

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Home Cancer information Types of cancer Ovarian cancer. Ovarian cancer Contents: Overview Diagnosing ovarian cancer Treatment for ovarian cancer Managing side effects of ovarian cancer. What is ovarian cancer? The ovaries The ovaries are part of the female reproductive system, which also includes the fallopian tubes, uterus womb , cervix the neck of the uterus , vagina birth canal and vulva external genitals.

Each ovary is made up of: epithelial cells — found on the outside of the ovary in a layer known as the epithelium germinal germ cells — found inside the ovaries, these cells eventually mature into eggs ova stromal cells — form connective supporting tissue within the ovaries, and produce the female hormones oestrogen and progesterone. What types are there? How common is it? What are the symptoms? How important are genetic factors? Most women diagnosed with ovarian cancer do not have a family history of the disease. What are the risk factors?

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Ovarian cancer - Cancer Council Australia

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Legal and financial advice. Financial assistance. Work How to manage a work life and cancer. Holiday break program. Holiday break program Free short breaks for those affected by cancer and their families. Cancer services guide. As the cancer progresses, signs and symptoms can include pain or a feeling of heaviness in the pelvis or lower abdomen, bloating, feeling full quickly when eating, back pain, vaginal bleeding between menstrual periods or after menopause, or changes in urinary or bowel habits.

However, these changes can occur as part of many different conditions. Having one or more of these symptoms does not mean that a woman has ovarian cancer. In some cases, cancerous tumors can invade surrounding tissue and spread to other parts of the body. If ovarian cancer spreads, cancerous tumors most often appear in the abdominal cavity or on the surfaces of nearby organs such as the bladder or colon.

Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. Some ovarian cancers cluster in families. These cancers are described as hereditary and are associated with inherited gene mutations. Hereditary ovarian cancers tend to develop earlier in life than non-inherited sporadic cases. Because it is often diagnosed at a late stage, ovarian cancer can be difficult to treat; it leads to the deaths of about 14, women annually in the United States, more than any other gynecological cancer. However, when it is diagnosed and treated early, the 5-year survival rate is high.

Ovarian cancer is diagnosed in about 22, women in the United States each year. A woman's lifetime risk of developing ovarian cancer is about 1 in Cancers occur when a buildup of mutations in critical genes—those that control cell growth and division or repair damaged DNA—allow cells to grow and divide uncontrollably to form a tumor. Most cases of ovarian cancer are sporadic; in these cases the associated genetic changes are acquired during a person's lifetime and are present only in certain cells in the ovary.

Symptoms of ovarian cancer

These changes, which are called somatic mutations, are not inherited. Somatic mutations in the TP53 gene occur in almost half of all ovarian cancers. The protein produced from this gene is described as a tumor suppressor because it helps keep cells from growing and dividing too fast or in an uncontrolled way. Most of these mutations change single protein building blocks amino acids in the p53 protein, which reduces or eliminates the protein's tumor suppressor function.

Because the altered protein is less able to regulate cell growth and division, a cancerous tumor may develop. Somatic mutations in many other genes have also been found in ovarian cancer cells. In hereditary ovarian cancer , the associated genetic changes are passed down within a family. These changes, classified as germline mutations, are present in all the body's cells. In people with germline mutations, other inherited and somatic gene changes, together with environmental and lifestyle factors, also influence whether a woman will develop ovarian cancer.

Germline mutations are involved in more than one-fifth of ovarian cancer cases. These gene mutations are described as "high penetrance" because they are associated with a high risk of developing ovarian cancer , breast cancer , and several other types of cancer in women. Compared to a 1. Men with mutations in these genes also have an increased risk of developing several forms of cancer.

As these defects accumulate, they can trigger cells to grow and divide without control or order to form a tumor. A significantly increased risk of ovarian cancer is also a feature of certain rare genetic syndromes, including a disorder called Lynch syndrome. Lynch syndrome is most often associated with mutations in the MLH1 or MSH2 gene and accounts for between 10 and 15 percent of hereditary ovarian cancers. Other rare genetic syndromes may also be associated with an increased risk of ovarian cancer. The proteins produced from the genes associated with these syndromes act as tumor suppressors.

Mutations in any of these genes can allow cells to grow and divide unchecked, leading to the development of a cancerous tumor. In addition to ovarian cancer , mutations in these genes increase the risk of several other types of cancer in both men and women.

Symptoms and Detection

Germline mutations in dozens of other genes have been studied as possible risk factors for ovarian cancer. These genes are described as "low penetrance" or "moderate penetrance" because changes in each of these genes appear to make only a small or moderate contribution to overall ovarian cancer risk.

Others act through different pathways. Researchers suspect that the combined influence of variations in these genes may significantly impact a person's risk of developing ovarian cancer. In many families, the genetic changes associated with hereditary ovarian cancer are unknown.

Ovarian Cancer

Identifying additional genetic risk factors for ovarian cancer is an active area of medical research. In addition to genetic changes, researchers have identified many personal and environmental factors that contribute to a woman's risk of developing ovarian cancer. These factors include age, ethnic background, and hormonal and reproductive factors. A history of ovarian cancer in closely related family members is also an important risk factor, particularly if the cancer occurred in early adulthood.